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BCD1 Bcd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856436, updated on 18-Sep-2024

Summary

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Official Symbol
BCD1
Official Full Name
Bcd1p
Primary source
SGD:S000001082
Locus tag
YHR040W
See related
AllianceGenome:SGD:S000001082; FungiDB:YHR040W; VEuPathDB:YHR040W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables snoRNA binding activity. Involved in box C/D snoRNP assembly; ribosome biogenesis; and sno(s)RNA metabolic process. Located in cytoplasm and nucleus. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BCD1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (187924..189024)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene meiotic recombination directing protein Neighboring gene H(+)-transporting V1 sector ATPase subunit G Neighboring gene Srb2p Neighboring gene NADPH--hemoprotein reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Bragantini B, et al. Nat Commun, 2021 Mar 25. PMID 33767140, Free PMC Article
  2. A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis. Khoshnevis S, et al. J Biol Chem, 2019 Nov 29. PMID 31537647, Free PMC Article
  3. Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis. Bragantini B, et al. J Mol Biol, 2016 Jun 5. PMID 27139642
  4. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis. Paul A, et al. RNA, 2019 Apr. PMID 30700579, Free PMC Article
  5. A panoramic view of yeast noncoding RNA processing. Peng WT, et al. Cell, 2003 Jun 27. PMID 12837249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.
    Title: The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.
  2. Bcd1 is required for interactions with box C/D snoRNAs including RNA binding protein SNU13 (Snu13).
    Title: A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis.
  3. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
    Title: Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
  4. The authors identified structural features associated with the requirement of Hit1p and Bcd1p zinc finger-HIT domain for cell growth and box C/D snoRNA stability under heat stress. Altogether, the data suggest an important role of zinc finger-HIT domain could be to maintain functional folding to the rest of the protein, especially under heat stress conditions.
    Title: Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in box C/D snoRNP assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in sno(s)RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snoRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pre-snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Bcd1p
NP_011906.1
  • Essential protein required for the accumulation of box C/D snoRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    187924..189024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179170.1 → NP_011906.1  TPA: Bcd1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011906.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY8, P38772
    UniProtKB/TrEMBL
    A6ZSU7, B3LSG0, C7GTU0, C8ZAB1, G2WFB3, N1P3A4
    Conserved Domains (1) summary
    pfam04438
    Location:1 → 31
    zf-HIT; HIT zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38772.1

Gene LinkOut

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