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MUP3 Mup3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856349, updated on 18-Sep-2024

Summary

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Official Symbol
MUP3
Official Full Name
Mup3p
Primary source
SGD:S000001028
Locus tag
YHL036W
See related
AllianceGenome:SGD:S000001028; FungiDB:YHL036W; VEuPathDB:YHL036W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-methionine transmembrane transporter activity. Involved in methionine import across plasma membrane. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in cystinuria and lysinuric protein intolerance. Orthologous to several human genes including SLC7A10 (solute carrier family 7 member 10); SLC7A11 (solute carrier family 7 member 11); and SLC7A13 (solute carrier family 7 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MUP3 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (26241..27881)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Cbp2p Neighboring gene uncharacterized protein Neighboring gene putative ATP-binding cassette multidrug transporter VMR1 Neighboring gene Sbp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases. Isnard AD, et al. J Mol Biol, 1996 Oct 4. PMID 8893857
  2. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Shimada K, et al. Mol Cell, 2013 Sep 26. PMID 24035500
  3. Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake. dos Santos SC, et al. Antimicrob Agents Chemother, 2009 Dec. PMID 19805573, Free PMC Article
  4. Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs. Holmes KJ, et al. PLoS One, 2013. PMID 24386330, Free PMC Article
  5. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. Figley MD, et al. J Neurosci, 2014 Jun 11. PMID 24920614, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-methionine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-methionine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in methionine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mup3p
NP_011827.1
  • Low affinity methionine permease; similar to Mup1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    26241..27881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179116.1 → NP_011827.1  TPA: Mup3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011827.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKT2, P38734
    UniProtKB/TrEMBL
    A6ZSL4, B3LS83, B5VJP0, C8ZA26, G2WF29, N1P545
    Conserved Domains (1) summary
    TIGR00911
    Location:40 → 538
    2A0308; L-type amino acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38734.1

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