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COS8 Cos8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856337, updated on 2-Nov-2024

Summary

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Official Symbol
COS8
Official Full Name
Cos8p
Primary source
SGD:S000001040
Locus tag
YHL048W
See related
AllianceGenome:SGD:S000001040; FungiDB:YHL048W; VEuPathDB:YHL048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COS8 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (6401..7546)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene siderophore transporter Neighboring gene seripauperin PAU13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Finding undetected protein associations in cell signaling by belief propagation. Bailly-Bechet M, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187432, Free PMC Article
  2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
  3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
  4. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. Gulati S, et al. FASEB J, 2015 Nov. PMID 26220175, Free PMC Article
  5. A family of tetraspans organizes cargo for sorting into multivesicular bodies. MacDonald C, et al. Dev Cell, 2015 May 4. PMID 25942624, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cos8p
NP_011815.1
  • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    6401..7546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179128.1 → NP_011815.1  TPA: Cos8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011815.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKS3, P38723
    Conserved Domains (1) summary
    pfam00674
    Location:261 → 353
    DUP; DUP family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38723.1

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