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SMX3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856312, updated on 11-Sep-2024

Summary

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Official Symbol
SMX3
Primary source
SGD:S000006386
Locus tag
YPR182W
See related
AllianceGenome:SGD:S000006386; FungiDB:YPR182W; VEuPathDB:YPR182W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables poly(U) RNA binding activity and splicing factor binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of spliceosomal snRNP complex. Orthologous to human SNRPF (small nuclear ribonucleoprotein polypeptide F). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (900194..900454)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene E1 ubiquitin-activating protein AOS1 Neighboring gene GTPase-activating protein SEC23 Neighboring gene dolichyl-phosphate beta-D-mannosyltransferase Neighboring gene bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antibodies to yeast Sm motif 1 cross-react with human Sm core polypeptides. Bahia D, et al. Eur J Biochem, 1999 Apr. PMID 10215846
  2. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins BM, et al. J Biol Chem, 2003 May 9. PMID 12618433
  3. Functional characterization of nuclear localization signals in yeast Sm proteins. Bordonné R. Mol Cell Biol, 2000 Nov. PMID 11027265, Free PMC Article
  4. Lsm Proteins are required for normal processing and stability of ribosomal RNAs. Kufel J, et al. J Biol Chem, 2003 Jan 24. PMID 12438310
  5. Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke S, et al. J Mol Biol, 2001 Apr 20. PMID 11302706

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables splicing factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sm-like protein family complex IEA
Inferred from Electronic Annotation
more info
  
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA splicing protein SMX3
NP_015508.1
  • Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    900194..900454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184279.1 → NP_015508.1  TPA: mRNA splicing protein SMX3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015508.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4I2, P54999
    UniProtKB/TrEMBL
    A6ZX56, B3LKE1, C7GP64, C8ZJL1, G2WPZ3, N1NXW1
    Conserved Domains (1) summary
    cd01722
    Location:14 → 83
    Sm_F; Sm protein F
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54999.1

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