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NUT2 mediator complex subunit NUT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856297, updated on 14-Nov-2024

Summary

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Official Symbol
NUT2
Official Full Name
mediator complex subunit NUT2
Primary source
SGD:S000006372
Locus tag
YPR168W
See related
AllianceGenome:SGD:S000006372; FungiDB:YPR168W; VEuPathDB:YPR168W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED10
Summary
Predicted to enable transcription coregulator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NUT2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (878076..878549)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRP2 Neighboring gene phosphoadenylyl-sulfate reductase (thioredoxin) Neighboring gene Jip5p Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator complex subunit NUT2
NP_015494.1
  • Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    878076..878549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184265.1 → NP_015494.1  TPA: mediator complex subunit NUT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4G9, Q06213
    UniProtKB/TrEMBL
    A6ZX44, B3LKC9, C7GP51, C8ZJJ4, G2WPY1, N1NW65
    Conserved Domains (1) summary
    pfam09748
    Location:19 → 142
    Med10; Transcription factor subunit Med10 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06213.1

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