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PIN3 Pin3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856277, updated on 2-Nov-2024

Summary

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Official Symbol
PIN3
Official Full Name
Pin3p
Primary source
SGD:S000006358
Locus tag
YPR154W
See related
AllianceGenome:SGD:S000006358; FungiDB:YPR154W; VEuPathDB:YPR154W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LSB2
Summary
Involved in negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PIN3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (834565..835212)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Urn1p Neighboring gene May24p Neighboring gene Nca2p Neighboring gene spermine transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress. Chernova TA, et al. Cell Rep, 2017 Jan 17. PMID 28099852, Free PMC Article
  2. Prion-based memory of heat stress in yeast. Chernova TA, et al. Prion, 2017 May 4. PMID 28521568, Free PMC Article
  3. Prions affect the appearance of other prions: the story of [PIN(+)]. Derkatch IL, et al. Cell, 2001 Jul 27. PMID 11511345
  4. Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis. Spiess M, et al. PLoS One, 2013. PMID 23577202, Free PMC Article
  5. Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro. Kaminska J, et al. Eur J Cell Biol, 2011 Dec. PMID 22000681

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pin3p
NP_015480.1
  • Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    834565..835212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184251.1 → NP_015480.1  TPA: Pin3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4F0, Q06449
    UniProtKB/TrEMBL
    C7GXT9, C8ZJH8, N1NVL9
    Conserved Domains (1) summary
    cl17036
    Location:58 → 110
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06449.1

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