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MEP3 ammonium permease MEP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856260, updated on 1-Aug-2024

Summary

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Gene symbol
MEP3
Gene description
ammonium permease MEP3
Primary source
FungiDB:YPR138C
Locus tag
YPR138C
See related
SGD:S000006342; AllianceGenome:SGD:S000006342; VEuPathDB:YPR138C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ammonium transmembrane transporter activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MEP3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (810984..812453, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Asn Neighboring gene lysophosphatidic acid acyltransferase LOA1 Neighboring gene lysophosphatidylcholine acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily. Ariz I, et al. Sci Adv, 2018 Sep. PMID 30214933, Free PMC Article
  2. Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Teichert S, et al. Eukaryot Cell, 2008 Feb. PMID 18083831, Free PMC Article
  3. Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Van Nuland A, et al. Mol Microbiol, 2006 Mar. PMID 16468990
  4. Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism. Smith DG, et al. Mol Microbiol, 2003 Oct. PMID 14507379
  5. Homo- and hetero-oligomerization of ammonium transporter-1 NH4 uniporters. Ludewig U, et al. J Biol Chem, 2003 Nov 14. PMID 12952951

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ammonium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ammonium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ammonium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ammonium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ammonium transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ammonium transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ammonium permease MEP3
NP_015464.1
  • Ammonium permease of high capacity and low affinity; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation ammonia permease activity regulated by TORC1 effectors, Npr1p and Par32p; MEP3 has a paralog, MEP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    810984..812453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184235.1 → NP_015464.1  TPA: ammonium permease MEP3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015464.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4D6, P53390, Q6B2F5
    UniProtKB/TrEMBL
    A6ZX15, B3LK99, B5VTS5, C7GLJ8, C8ZJG1, N1NW55
    Conserved Domains (1) summary
    COG0004
    Location:13 → 430
    AmtB; Ammonia channel protein AmtB [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53390.1

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