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RPS23B ribosomal 40S subunit protein S23B [ Saccharomyces cerevisiae S288C ]

Gene ID: 856250, updated on 2-Nov-2024

Summary

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Official Symbol
RPS23B
Official Full Name
ribosomal 40S subunit protein S23B
Primary source
SGD:S000006336
Locus tag
YPR132W
See related
AllianceGenome:SGD:S000006336; FungiDB:YPR132W; VEuPathDB:YPR132W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of translational fidelity. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in brachycephaly, trichomegaly, and developmental delay. Orthologous to human RPS23 (ribosomal protein S23). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPS23B in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (794965..795767)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Scd6p Neighboring gene peptide alpha-N-acetyltransferase complex B subunit NAT3 Neighboring gene Spn1p Neighboring gene Tom5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. Alksne LE, et al. J Biol Chem, 1993 May 25. PMID 8496146
  2. An accuracy center in the ribosome conserved over 2 billion years. Alksne LE, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415737, Free PMC Article
  3. Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Synetos D, et al. Biochim Biophys Acta, 1996 Nov 11. PMID 8950190
  4. Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA. Panopoulos P, et al. Nucleic Acids Res, 2004. PMID 15477390, Free PMC Article
  5. Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Anthony RA, et al. Genetics, 1995 Aug. PMID 7498767, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational fidelity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 40S subunit protein S23B
NP_015457.1
  • Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    794965..795767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184229.1 → NP_015457.1  TPA: ribosomal 40S subunit protein S23B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUP9, P0CX29, P0CX30, P32827
    UniProtKB/TrEMBL
    A6ZUD1, B3LIB1, C8Z909, C8ZJF4, G2WEK0, N1P5W3
    Conserved Domains (1) summary
    PTZ00067
    Location:4 → 145
    PTZ00067; 40S ribosomal S23; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX29.1
P0CX30.1

Gene LinkOut

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Research Materials
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