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MRPL51 mitochondrial 54S ribosomal protein MRPL51 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856214, updated on 2-Nov-2024

Summary

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Official Symbol
MRPL51
Official Full Name
mitochondrial 54S ribosomal protein MRPL51
Primary source
SGD:S000006304
Locus tag
YPR100W
See related
AllianceGenome:SGD:S000006304; FungiDB:YPR100W; VEuPathDB:YPR100W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
mL43
Summary
A structural constituent of ribosome. Involved in cell redox homeostasis and mitochondrial genome maintenance. Located in mitochondrion. Part of mitochondrial large ribosomal subunit. Orthologous to human MRPL43 (mitochondrial ribosomal protein L43). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRPL51 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (729791..730213)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Lec1p Neighboring gene Tmh18p Neighboring gene uncharacterized protein Neighboring gene Snt309p Neighboring gene ribosomal 60S subunit protein L11A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reverse genetic analysis of yeast YPR099C/MRPL51 reveals a critical role of both overlapping ORFs in respiratory growth and MRPL51 in mitochondrial DNA maintenance. Sahu PK, et al. FEMS Yeast Res, 2019 Sep 1. PMID 31374566
  2. Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity. Smith MR, et al. Appl Environ Microbiol, 2013 Jan. PMID 23144132, Free PMC Article
  3. Structure of the yeast mitochondrial large ribosomal subunit. Amunts A, et al. Science, 2014 Mar 28. PMID 24675956, Free PMC Article
  4. Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components. Gan X, et al. Eur J Biochem, 2002 Nov. PMID 12392552
  5. Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. Frazier AE, et al. J Cell Biol, 2006 Feb 13. PMID 16476776, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanism of mitochondrial DNA (mtDNA ) maintenance by Mrpl51 is probably Mhr1 dependent that physically interacts with Mrpl51 and also regulates mtDNA repair.
    Title: Reverse genetic analysis of yeast YPR099C/MRPL51 reveals a critical role of both overlapping ORFs in respiratory growth and MRPL51 in mitochondrial DNA maintenance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial 54S ribosomal protein MRPL51
NP_015425.1
  • Mitochondrial ribosomal protein of the large subunit; required for mitochondrial genome integrity, respiratory growth, and mitochondrial redox homeostasis, partially overlaps verified gene YPR099C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    729791..730213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184197.1 → NP_015425.1  TPA: mitochondrial 54S ribosomal protein MRPL51 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W498, Q06090
    UniProtKB/TrEMBL
    A6ZWY0, B3LK64, C7GPT8, C8ZJC2, G2WPR6, N1NXP0
    Conserved Domains (1) summary
    smart00916
    Location:35 → 104
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06090.1

Gene LinkOut

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