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MRL1 Mrl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856194, updated on 2-Nov-2024

Summary

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Official Symbol
MRL1
Official Full Name
Mrl1p
Primary source
SGD:S000006283
Locus tag
YPR079W
See related
AllianceGenome:SGD:S000006283; FungiDB:YPR079W; VEuPathDB:YPR079W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables signal sequence binding activity. Involved in vacuolar transport. Located in late endosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRL1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (698869..700014)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Opy2p Neighboring gene uncharacterized protein Neighboring gene translation elongation factor EF-1 alpha Neighboring gene putative glycine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases. Whyte JR, et al. Curr Biol, 2001 Jul 10. PMID 11470415
  2. Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. Itoh T, et al. EMBO J, 2004 Jul 7. PMID 15201867, Free PMC Article
  3. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. Wang Y, et al. J Cell Biol, 2020 May 4. PMID 32303746, Free PMC Article
  4. The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat. Shortill SP, et al. Elife, 2022 Aug 8. PMID 35938928, Free PMC Article
  5. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mrl1 is a mitochondrial factor for myo2p-dependent inheritance of mitochondria.
    Title: Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables signal sequence binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mrl1p
NP_015404.1
  • Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    698869..700014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184176.1 → NP_015404.1  TPA: Mrl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W481, Q06815
    UniProtKB/TrEMBL
    A6ZWW4, B3LK49, B5VTM4, G2WPP9, N1P276
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06815.1

Gene LinkOut

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