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APL4 Apl4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856141, updated on 18-Sep-2024

Summary

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Official Symbol
APL4
Official Full Name
Apl4p
Primary source
SGD:S000006233
Locus tag
YPR029C
See related
AllianceGenome:SGD:S000006233; FungiDB:YPR029C; VEuPathDB:YPR029C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables clathrin binding activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1) and AP1G2 (adaptor related protein complex 1 subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See APL4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (624469..626967, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene Yop1p Neighboring gene Csr2p Neighboring gene Nto1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maturation-driven transport and AP-1-dependent recycling of a secretory cargo in the Golgi. Casler JC, et al. J Cell Biol, 2019 May 6. PMID 30858194, Free PMC Article
  2. Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats. Yeung BG, et al. Traffic, 2001 Aug. PMID 11489214
  3. A microscopy-based kinetic analysis of yeast vacuolar protein sorting. Casler JC, et al. Elife, 2020 Jun 25. PMID 32584255, Free PMC Article
  4. Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. Duncan MC, et al. Nat Cell Biol, 2003 Jan. PMID 12483220
  5. Plasma membrane to vacuole traffic induced by glucose starvation requires Gga2-dependent sorting at the trans-Golgi network. Buelto D, et al. Biol Cell, 2020 Nov. PMID 32761633, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-1 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-1 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apl4p
NP_015354.1
  • Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    624469..626967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184126.1 → NP_015354.1  TPA: Apl4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015354.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W439, Q12028
    UniProtKB/TrEMBL
    A6ZWS2, N1NW08
    Conserved Domains (2) summary
    smart00809
    Location:727 → 828
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:21 → 617
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12028.1

Gene LinkOut

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