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CTF19 Ctf19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856089, updated on 2-Nov-2024

Summary

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Official Symbol
CTF19
Official Full Name
Ctf19p
Primary source
SGD:S000005939
Locus tag
YPL018W
See related
AllianceGenome:SGD:S000005939; FungiDB:YPL018W; VEuPathDB:YPL018W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MCM18
Summary
Involved in several processes, including attachment of spindle microtubules to kinetochore; establishment of mitotic sister chromatid cohesion; and mitotic spindle assembly checkpoint signaling. Located in kinetochore and nucleus. Part of COMA complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CTF19 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (517651..518760)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene SUMO protease ULP1 Neighboring gene vacuolar transporter chaperone Neighboring gene Irc15p Neighboring gene Swi1p Neighboring gene histone deacetylase HST2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae. Mehta GD, et al. Mol Microbiol, 2014 Mar. PMID 24446862
  2. Budding yeast kinetochore proteins, Chl4 and Ctf19, are required to maintain SPB-centromere proximity during G1 and late anaphase. Sau S, et al. PLoS One, 2014. PMID 25003500, Free PMC Article
  3. Role of Ctf3 and COMA subcomplexes in meiosis: Implication in maintaining Cse4 at the centromere and numeric spindle poles. Agarwal M, et al. Biochim Biophys Acta, 2015 Mar. PMID 25562757
  4. The [PSI (+)] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI (+)] cells can promote aneuploidy. Chan PHW, et al. Sci Rep, 2017 Aug 16. PMID 28814753, Free PMC Article
  5. Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae. Petrie MV, et al. Genes (Basel), 2022 Nov 24. PMID 36553469, Free PMC Article

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae.
    Title: Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae.
  2. Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
    Title: Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
  3. The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19(CCAN) Complex in Meiotic Kinetochore Assembly.
    Title: The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19(CCAN) Complex in Meiotic Kinetochore Assembly.
  4. A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination.
    Title: A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination.
  5. Ctf19 is also essential for meiosis I specific unique events, such as non-homologous centromere coupling, homologue pairing, chiasmata resolution and proper orientation of homologues and sister chromatids with respect to the spindle poles.
    Title: Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae.
  6. The Ctf19 complex is required for Scc2 enrichment at the centromere.
    Title: Cohesin-dependent association of scc2/4 with the centromere initiates pericentromeric cohesion establishment.
  7. Ctf19 and Csm3 are both important mediators of pericentromeric cohesion.
    Title: Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COMA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ctf19p
NP_015307.1
  • Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    517651..518760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183832.1 → NP_015307.1  TPA: Ctf19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015307.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Z4, Q02732
    UniProtKB/TrEMBL
    A6ZWM8, C8ZJ10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02732.1

Gene LinkOut

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