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NOP4 mRNA-binding ribosome biosynthesis protein NOP4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856063, updated on 3-Nov-2024

Summary

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Official Symbol
NOP4
Official Full Name
mRNA-binding ribosome biosynthesis protein NOP4
Primary source
SGD:S000005964
Locus tag
YPL043W
See related
AllianceGenome:SGD:S000005964; FungiDB:YPL043W; VEuPathDB:YPL043W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NOP77
Summary
Enables mRNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NOP4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (469939..471996)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene elongin C Neighboring gene tethering complex subunit VPS16 Neighboring gene cyclin-dependent serine/threonine protein kinase SSN3 Neighboring gene Mrx11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits. Sun C, et al. EMBO J, 1994 Jul 1. PMID 8039505, Free PMC Article
  2. The yeast nucleolar protein Nop4p contains four RNA recognition motifs necessary for ribosome biogenesis. Sun C, et al. J Biol Chem, 1997 Oct 3. PMID 9312154
  3. Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification. Bergès T, et al. EMBO J, 1994 Jul 1. PMID 8039506, Free PMC Article
  4. Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Gautier T, et al. Mol Cell Biol, 1997 Dec. PMID 9372940, Free PMC Article
  5. Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae. Qiu H, et al. Mol Cell Biol, 2008 Jun. PMID 18378690, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA-binding ribosome biosynthesis protein NOP4
NP_015282.1
  • Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    469939..471996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183857.1 → NP_015282.1  TPA: mRNA-binding ribosome biosynthesis protein NOP4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015282.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3X0, P37838
    UniProtKB/TrEMBL
    A6ZWK4, C7GU10, N1NW50
    Conserved Domains (4) summary
    cd12674
    Location:26 → 104
    RRM1_Nop4p; RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
    cd12675
    Location:147 → 229
    RRM2_Nop4p; RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
    cd12676
    Location:289 → 387
    RRM3_Nop4p; RNA recognition motif 3 (RRM3) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
    cd12677
    Location:458 → 620
    RRM4_Nop4p; RNA recognition motif 4 (RRM4) found in yeast nucleolar protein 4 (Nop4p) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37838.1

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