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SUR1 mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856050, updated on 2-Nov-2024

Summary

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Official Symbol
SUR1
Official Full Name
mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
Primary source
SGD:S000005978
Locus tag
YPL057C
See related
AllianceGenome:SGD:S000005978; FungiDB:YPL057C; VEuPathDB:YPL057C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BCL21; CSG1; LPE15
Summary
Enables inositol phosphorylceramide mannosyltransferase activity. Involved in glycosphingolipid biosynthetic process and mannosyl-inositol phosphorylceramide metabolic process. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SUR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (451909..453057, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene monothiol glutaredoxin GRX5 Neighboring gene ATP-binding cassette multidrug transporter PDR12 Neighboring gene Lcl1p Neighboring gene Lge1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast lipid analysis and quantification by mass spectrometry. Guan XL, et al. Methods Enzymol, 2010. PMID 20946818
  2. Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily. Fu D, et al. Yeast, 1995 Mar. PMID 7785328
  3. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Thevissen K, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931938, Free PMC Article
  4. Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis. da Silveira Dos Santos AX, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143408, Free PMC Article
  5. Improvement of d-Lactic Acid Production in Saccharomyces cerevisiae Under Acidic Conditions by Evolutionary and Rational Metabolic Engineering. Baek SH, et al. Biotechnol J, 2017 Oct. PMID 28731533

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
    Title: Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
  2. Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
    Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphorylceramide mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphorylceramide mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycosphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol phosphoceramide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannosyl-inositol phosphorylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannosyl-inositol phosphorylceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
NP_015268.1
  • Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    451909..453057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183871.1 → NP_015268.1  TPA: mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V7, P33300
    UniProtKB/TrEMBL
    A6ZWJ1, C7GTZ9, C8ZIX3, N1NW47
    Conserved Domains (1) summary
    COG3774
    Location:1 → 322
    OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33300.1

Gene LinkOut

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