NOG1 putative GTPase NOG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: NOG1
Official Full Name: putative GTPase NOG1
Primary source: SGD:S000006014
Locus tag: YPL093W
See related: AllianceGenome:SGD:S000006014; FungiDB:YPL093W; VEuPathDB:YPL093W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable GTP binding activity; GTPase activity; and RNA binding activity. Involved in assembly of large subunit precursor of preribosome; rRNA processing; and ribosomal subunit export from nucleus. Located in cytoplasm and nucleolus. Part of preribosome, large subunit precursor. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers.
Title: The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers.
Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
Title: Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
analysis of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1
Title: In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1.
Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR.
Title: TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in assembly of large subunit precursor of preribosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed

NP_015232.1

Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins

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