SEC62 Sec63 complex subunit SEC62 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SEC62
Gene description: Sec63 complex subunit SEC62
Primary source: FungiDB:YPL094C
Locus tag: YPL094C
See related: SGD:S000006015; AllianceGenome:SGD:S000006015; VEuPathDB:YPL094C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPG14
Summary: Enables protein transmembrane transporter activity. Involved in posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Part of Sec62/Sec63 complex. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC62 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (369839..370663, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endoplasmic reticulum-resident protein Sec62 drives colorectal cancer metastasis via MAPK/ATF2/UCA1 axis.
Title: Endoplasmic reticulum-resident protein Sec62 drives colorectal cancer metastasis via MAPK/ATF2/UCA1 axis.
Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments.
Title: Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments.
Effect of Sec62 on the conformation of the Sec61 channel in yeast.
Title: Effect of Sec62 on the conformation of the Sec61 channel in yeast.
Architecture of the active post-translational Sec translocon.
Title: Architecture of the active post-translational Sec translocon.
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
Title: Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
Data indicate that defect in Sec62 selectively reduced signal sequences inserted in an N(in)-C(out) (type II) membrane topology.
Title: Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER).

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Sec62/Sec63 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sec63 complex subunit SEC62

NP_015231.2

Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

369839..370663 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183908.1 → NP_015231.2 TPA: Sec63 complex subunit SEC62 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015231.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3S3, P21825

UniProtKB/TrEMBL

A6ZWF7, B3LKX9, C7GJ48, G2WP87, N1NVH1

Conserved Domains (1) summary

COG5232
Location:1 → 259

SEC62; Preprotein translocase subunit Sec62 [Intracellular trafficking and secretion]