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ELP4 Elongator subunit ELP4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856002, updated on 3-Nov-2024

Summary

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Official Symbol
ELP4
Official Full Name
Elongator subunit ELP4
Primary source
SGD:S000006022
Locus tag
YPL101W
See related
AllianceGenome:SGD:S000006022; FungiDB:YPL101W; VEuPathDB:YPL101W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAP1; KTI9; TOT7
Summary
Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm. Part of elongator holoenzyme complex. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ELP4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (360209..361579)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene aspartate--tRNA ligase MSD1 Neighboring gene N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D Neighboring gene Atg21p Neighboring gene Ina17p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [The Elp4 subunit of human Elongator complex partially complements the growth defects of yeast ELP4 deletion strain]. Li F, et al. Yi Chuan Xue Bao, 2004 Jul. PMID 15473317
  2. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
  3. Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Jablonowski D, et al. Mol Microbiol, 2001 Nov. PMID 11737649
  4. Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. Petrakis TG, et al. J Biol Chem, 2005 May 20. PMID 15772087
  5. Crystal structure of elongator subcomplex Elp4-6. Lin Z, et al. J Biol Chem, 2012 Jun 15. PMID 22556426, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Elongator subunit ELP4
NP_015224.1
  • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    360209..361579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183915.1 → NP_015224.1  TPA: Elongator subunit ELP4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015224.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3R5, Q02884
    UniProtKB/TrEMBL
    B3LKX1, B5VT61, C8ZIS9, N1NW31
    Conserved Domains (1) summary
    pfam05625
    Location:70 → 456
    PAXNEB; PAXNEB protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02884.1

Gene LinkOut

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