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PRP46 mRNA splicing protein PRP46 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855952, updated on 2-Nov-2024

Summary

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Official Symbol
PRP46
Official Full Name
mRNA splicing protein PRP46
Primary source
SGD:S000006072
Locus tag
YPL151C
See related
AllianceGenome:SGD:S000006072; FungiDB:YPL151C; VEuPathDB:YPL151C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NTC50
Summary
Involved in mRNA splicing, via spliceosome. Part of Prp19 complex and spliceosomal complex. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRP46 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (266180..267535, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene peptidylprolyl isomerase RRD2 Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Atg5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144
  2. RPA resolves conflicting activities of accessory proteins during reconstitution of Dmc1-mediated meiotic recombination. Chan YL, et al. Nucleic Acids Res, 2019 Jan 25. PMID 30462332, Free PMC Article
  3. Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates. Gahura O, et al. J Cell Biochem, 2009 Jan 1. PMID 19016306
  4. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
  5. Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. Ohi MD, et al. RNA, 2002 Jun. PMID 12088152, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA splicing protein PRP46
NP_015174.1
  • Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    266180..267535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183965.1 → NP_015174.1  TPA: mRNA splicing protein PRP46 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015174.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3L8, Q12417
    UniProtKB/TrEMBL
    A6ZWA3, C8ZIM8, G2WP32, N1NW12
    Conserved Domains (2) summary
    cd00200
    Location:131 → 427
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:144 → 180
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12417.1

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