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AIM44 Aim44p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855945, updated on 2-Nov-2024

Summary

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Official Symbol
AIM44
Official Full Name
Aim44p
Primary source
SGD:S000006079
Locus tag
YPL158C
See related
AllianceGenome:SGD:S000006079; FungiDB:YPL158C; VEuPathDB:YPL158C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GPS1
Summary
Involved in several processes, including cytokinetic process; protein localization to cell division site after cytokinesis; and regulation of protein localization to cell division site. Located in cleavage apparatus septin structure; nuclear inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AIM44 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (252034..254310, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene leucine--tRNA ligase CDC60 Neighboring gene Pet20p Neighboring gene RNA methyltransferase Neighboring gene pheromone-regulated protein PRM4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in budding yeast. Wolken DM, et al. Mol Biol Cell, 2014 Mar. PMID 24451263, Free PMC Article
  2. Cellular localization of Sun4p and its interaction with proteins in the yeast birth scar. Kuznetsov E, et al. Cell Cycle, 2016 Jul 17. PMID 27229769, Free PMC Article
  3. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Doolin MT, et al. Mol Microbiol, 2001 Apr. PMID 11309124
  4. The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Meitinger F, et al. Mol Biol Cell, 2017 Apr 1. PMID 28148650, Free PMC Article
  5. Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein. Miller KE, et al. Mol Biol Cell, 2017 Dec 15. PMID 29074565, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in Saccharomyces cerevisiae.
    Title: Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell division site after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to cell division site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secondary cell septum biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in secondary cell septum biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular bud neck IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cellular bud neck septin collar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck split septin rings IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip HDA PubMed 
located_in nuclear inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Aim44p
NP_015167.1
  • Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    252034..254310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183972.1 → NP_015167.1  TPA: Aim44p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015167.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZW95, B3LKR9, C8ZIM0, D6W3L0, Q99299
    UniProtKB/TrEMBL
    N1NVU3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99299.1

Gene LinkOut

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