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MEX67 Mex67p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855934, updated on 2-Nov-2024

Summary

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Official Symbol
MEX67
Official Full Name
Mex67p
Primary source
SGD:S000006090
Locus tag
YPL169C
See related
AllianceGenome:SGD:S000006090; FungiDB:YPL169C; VEuPathDB:YPL169C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables porin activity; snRNA binding activity; and tRNA binding activity. Involved in nuclear export and tRNA processing. Located in cytoplasm. Part of nuclear RNA export factor complex and nuclear pore. Is active in nucleus. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MEX67 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (229039..230838, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene NADPH dehydrogenase Neighboring gene Dap1p Neighboring gene Mrx4p Neighboring gene DNA-directed DNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear retention prevents premature cytoplasmic appearance of mRNA. Kallehauge TB, et al. Mol Cell, 2012 Oct 12. PMID 22921936
  2. In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p. Smith C, et al. J Cell Biol, 2015 Dec 21. PMID 26694837, Free PMC Article
  3. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Hieronymus H, et al. Nat Genet, 2003 Feb. PMID 12524544
  4. A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA. Tudek A, et al. Cell Rep, 2018 Aug 28. PMID 30157437, Free PMC Article
  5. The RNA export factor Mex67 functions as a mobile nucleoporin. Derrer CP, et al. J Cell Biol, 2019 Dec 2. PMID 31753862, Free PMC Article

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex.
    Title: Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm(7) complex.
  2. Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability.
    Title: Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability.
  3. Mex67 functions as a mobile nuclear pore complex (NPC) component, which receives mRNA export substrates in the central channel of the NPC to facilitate their translocation to the cytoplasm; this interaction is not affected by Dbp5, which is thought to remove Mex67 from transcripts
    Title: The RNA export factor Mex67 functions as a mobile nucleoporin.
  4. Mex67-Mtr2 functions in primary nuclear export for a subset of yeast tRNAs
    Title: Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.
  5. This study describes the mechanism of recruitment of the Saccharomyces cerevisiae RNA-export receptor Mex67-Mtr2 to the pre-60S subunit at the proper time. Mex67-Mtr2 binds at the premature ribosomal-stalk region, which later during translation serves as a binding platform for translational GTPases on the mature ribosome.
    Title: Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.
  6. show that the NTF2-like domain from Saccharomyces cerevisiae Mex67:Mtr2 also contributes to RNA binding
    Title: Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.
  7. Thus Mex67-Mtr2 is a unique transport receptor that employs a common interaction surface to participate in the nuclear export of both pre-ribosomal subunits and mRNAs
    Title: Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.
  8. Data indicate that Edc3p-mediated YRA1 pre-mRNA decay occurs independently of translation and also requires Mex67p.
    Title: Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.
  9. mutant Mex67-5p, but not wild-type Mex67p, is a target of the nuclear protein quality control mediated by San1p, a ubiquitin-protein ligase that participates in degradation of aberrant chromatin-associated proteins
    Title: A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.
  10. Nap1 interacts with the mRNA export factor Mex67.
    Title: Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U1 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U2 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U4 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U5 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA re-export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear RNA export factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mex67p
NP_015156.1
  • Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore and nuclear RNA export factor; ubiquitin-associated (UBA) domain interacts with Mip6p; ortholog of human TAP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    229039..230838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183983.1 → NP_015156.1  TPA: Mex67p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3J9, Q99257
    UniProtKB/TrEMBL
    B3LKQ9, C7GJC0, C8ZIK9, N1NWZ9
    Conserved Domains (4) summary
    smart00804
    Location:537 → 597
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:119 → 163
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam18444
    Location:23 → 92
    RRM_9; RNA recognition motif
    cd21340
    Location:155 → 256
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99257.1

Gene LinkOut

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