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PPQ1 protein-serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855923, updated on 18-Sep-2024

Summary

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Official Symbol
PPQ1
Official Full Name
protein-serine/threonine phosphatase
Primary source
SGD:S000006100
Locus tag
YPL179W
See related
AllianceGenome:SGD:S000006100; FungiDB:YPL179W; VEuPathDB:YPL179W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAL6
Summary
Enables phosphoprotein phosphatase activity. Involved in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion and protein dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PPQ1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (208157..209806)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cti6p Neighboring gene Tco89p Neighboring gene tRNA-Glu Neighboring gene nuclear cap-binding protein subunit CBC2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Large-scale functional analysis of the roles of phosphorylation in yeast metabolic pathways. Schulz JC, et al. Sci Signal, 2014 Nov 25. PMID 25429078
  2. Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae. Shim E, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24309106
  3. PPQ, a novel protein phosphatase containing a Ser + Asn-rich amino-terminal domain, is involved in the regulation of protein synthesis. Chen MX, et al. Eur J Biochem, 1993 Dec 1. PMID 8269960
  4. The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension. Vincent A, et al. Genetics, 1994 Nov. PMID 7851758, Free PMC Article
  5. Allosuppressors that enhance the efficiency of omnipotent suppressors in Saccharomyces cerevisiae. Song JM, et al. Genetics, 1987 Mar. PMID 3552876, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggest that Ppq1 functions as a negative regulator of mating MAPK pathway by dephosphorylating target pathway protein(s) and plays a key role in the control of the background signaling noise.
    Title: Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-serine/threonine phosphatase
NP_015146.1
  • Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    208157..209806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183993.1 → NP_015146.1  TPA: protein-serine/threonine phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015146.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3I9, P32945
    UniProtKB/TrEMBL
    A6ZW74, B3LKP9, B5VSZ3, C7GJC8, C8ZIJ9, G2WP03, N1NWP3
    Conserved Domains (1) summary
    cd07414
    Location:239 → 535
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32945.1

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