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RPL1A ribosomal 60S subunit protein L1A [ Saccharomyces cerevisiae S288C ]

Gene ID: 855881, updated on 2-Nov-2024

Summary

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Official Symbol
RPL1A
Official Full Name
ribosomal 60S subunit protein L1A
Primary source
SGD:S000006141
Locus tag
YPL220W
See related
AllianceGenome:SGD:S000006141; FungiDB:YPL220W; VEuPathDB:YPL220W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PUB2; SSM1
Summary
Predicted to enable RNA binding activity. Involved in ribosomal large subunit export from nucleus. Part of cytosolic large ribosomal subunit. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPL1A in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (135790..136443)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Fmp40p Neighboring gene flavin adenine dinucleotide transporter Neighboring gene Pcl8p Neighboring gene Arf family GTPase SAR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing the yeast 5 S RNA-protein complex by fluorescence and controlled proteolytic digestion. Yeh LC, et al. Arch Biochem Biophys, 1990 Feb 1. PMID 2407192
  2. Yeast 5S rRNA binding to ribosomal protein L1a alters the fluorescence of tryptophan residues lying outside the binding site. Yeh LC, et al. Biochimie, 1992 Nov. PMID 1477137
  3. The accessibility of yeast ribosomal protein L1 as probed by proteolysis and site-directed mutagenesis is different in intact 60 and 80 S ribosome. Lee JC, et al. J Biol Chem, 1996 Mar 29. PMID 8631769
  4. The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site. Turnbull K, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39217469, Free PMC Article
  5. The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Petitjean A, et al. Mol Cell Biol, 1995 Sep. PMID 7651424, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L1A
NP_015104.1
  • Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    135790..136443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184034.1 → NP_015104.1  TPA: ribosomal 60S subunit protein L1A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU14, P0CX43, P0CX44, P53030
    UniProtKB/TrEMBL
    A6ZU48, B3LHJ3, B5VIJ6, C7GN47, C8Z8B5, G2WDW8, G2WNW5, N1P598
    Conserved Domains (1) summary
    cl00322
    Location:1 → 217
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX43.1
P0CX44.1

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Research Materials
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