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MMT2 Mmt2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855877, updated on 2-Nov-2024

Summary

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Official Symbol
MMT2
Official Full Name
Mmt2p
Primary source
SGD:S000006145
Locus tag
YPL224C
See related
AllianceGenome:SGD:S000006145; FungiDB:YPL224C; VEuPathDB:YPL224C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MFT2
Summary
Predicted to enable monoatomic cation transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MMT2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (126634..128088, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene New1p Neighboring gene ribosome-associated Tef1p biogenesis chaperone CHP1 Neighboring gene Gre1p Neighboring gene Fmp40p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of two homologous yeast genes that encode mitochondrial iron transporters. Li L, et al. J Biol Chem, 1997 Nov 7. PMID 9353309
  2. Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. Ward DM, et al. J Biol Chem, 2018 Jul 6. PMID 29773647, Free PMC Article
  3. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. Li L, et al. J Biol Chem, 2014 Jun 13. PMID 24798331, Free PMC Article
  4. The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. Li L, et al. J Biol Chem, 2020 Feb 7. PMID 31896574, Free PMC Article
  5. A proteomic strategy for gaining insights into protein sumoylation in yeast. Denison C, et al. Mol Cell Proteomics, 2005 Mar. PMID 15542864

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
    Title: The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
  2. Mmt2 is a mitochondrial iron exporter. deletion of MMT1/MMT2 led to decreased cytosolic iron.
    Title: Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inorganic ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mmt2p
NP_015100.2
  • Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    126634..128088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184038.2 → NP_015100.2  TPA: Mmt2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015100.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3E6, Q08970
    UniProtKB/TrEMBL
    A6ZW31, C8ZIF5, N1NVN0
    Conserved Domains (1) summary
    COG0053
    Location:122 → 409
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08970.2

Gene LinkOut

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