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DIM1 putative dimethyladenosine transferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855862, updated on 2-Nov-2024

Summary

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Official Symbol
DIM1
Official Full Name
putative dimethyladenosine transferase
Primary source
SGD:S000006187
Locus tag
YPL266W
See related
AllianceGenome:SGD:S000006187; FungiDB:YPL266W; VEuPathDB:YPL266W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDH1
Summary
Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and rRNA modification. Part of 90S preribosome. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DIM1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (39121..40077)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol phospholipase C Neighboring gene Acm1p Neighboring gene dicarboxylic amino acid permease Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. Lafontaine D, et al. Genes Dev, 1995 Oct 15. PMID 7590228
  2. Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Lafontaine DL, et al. Mol Cell Biol, 1998 Apr. PMID 9528805, Free PMC Article
  3. Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin. Hermans N, et al. Sci Rep, 2017 Dec 1. PMID 29196662, Free PMC Article
  4. Sequence and structural evolution of the KsgA/Dim1 methyltransferase family. O'Farrell HC, et al. BMC Res Notes, 2008 Oct 29. PMID 18959795, Free PMC Article
  5. Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. Park AK, et al. Mol Phylogenet Evol, 2009 Feb. PMID 19017544

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
    Title: An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
  2. During 40S ribosome biogenesis Fap7 links formation of a translation intermediate to release of the assembly factor Dim1. Bypassing Fap7 increases frameshifting.
    Title: The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative dimethyladenosine transferase
NP_015057.1
  • Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    39121..40077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184080.1 → NP_015057.1  TPA: putative dimethyladenosine transferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3A4, P41819
    UniProtKB/TrEMBL
    A6ZVZ0, B3LKG7, C7GSG6, C8ZIB3, G2WNS0, N1NY06
    Conserved Domains (1) summary
    cl17173
    Location:28 → 317
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41819.1

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