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ERR2 phosphopyruvate hydratase ERR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855848, updated on 2-Nov-2024

Summary

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Official Symbol
ERR2
Official Full Name
phosphopyruvate hydratase ERR2
Primary source
SGD:S000006202
Locus tag
YPL281C
See related
AllianceGenome:SGD:S000006202; FungiDB:YPL281C; VEuPathDB:YPL281C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Predicted to be part of phosphopyruvate hydratase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERR2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (9557..10870, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Y' element ATP-dependent helicase protein 1 copy 7 Neighboring gene seripauperin PAU22 Neighboring gene glutathione-independent methylglyoxalase family protein Neighboring gene fluoride transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Pryde FE, et al. Yeast, 1995 Apr 15. PMID 7785338
  2. The Saccharomyces cerevisiae enolase-related regions encode proteins that are active enolases. Kornblatt MJ, et al. Yeast, 2013 Feb. PMID 23359425
  3. Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance. Nivedita N, et al. Front Microbiol, 2021. PMID 34566920, Free PMC Article
  4. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Phan VT, et al. Mol Cell Biol, 2010 May. PMID 20160012, Free PMC Article
  5. Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins. Morvan J, et al. J Cell Sci, 2015 Feb 15. PMID 25512335

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphopyruvate hydratase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphopyruvate hydratase ERR2
NP_015042.1
  • Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    9557..10870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184095.1 → NP_015042.1  TPA: phosphopyruvate hydratase ERR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W385, P0CX10, P0CX11, Q12007, Q7LGJ4
    UniProtKB/TrEMBL
    A6ZVX7, B3LK45, B5VSR2, C7GSW8, C8ZHE0
    Conserved Domains (1) summary
    PTZ00081
    Location:1 → 428
    PTZ00081; enolase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX10.1
P0CX11.1

Gene LinkOut

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