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SSO1 syntaxin [ Saccharomyces cerevisiae S288C ]

Gene ID: 855844, updated on 2-Nov-2024

Summary

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Official Symbol
SSO1
Official Full Name
syntaxin
Primary source
SGD:S000006153
Locus tag
YPL232W
See related
AllianceGenome:SGD:S000006153; FungiDB:YPL232W; VEuPathDB:YPL232W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNAP receptor activity and anion binding activity. Involved in ascospore-type prospore assembly and vesicle fusion. Located in fungal-type vacuole membrane; plasma membrane; and prospore membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in several diseases, including Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; familial hemophagocytic lymphohistiocytosis 4; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SSO1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (107275..108147)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit c' Neighboring gene MIND complex subunit NSL1 Neighboring gene trifunctional fatty acid synthase subunit FAS2 Neighboring gene Usv1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The shape of the exoplasmic hemi-transmembrane domain, in addition to the length of the entire transmembrane domain, determine retention in the Golgi or exit to the plasma membrane of SFT1 and SSO1 proteins.
    Title: Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex.
  2. The Sso1, but not SSo2, is essential for prospore membrane formation.
    Title: Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation.
  3. Data show that the required function of the NH2-terminal regulatory domain (NRD) of the yeast plasma membrane syntaxin, Sso1p, can be circumvented when t-SNARE complex formation is made intramolecular.
    Title: An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain.
  4. EPR analysis of spin-labeled mutants showed that the transmembrane domain of Sso1p is a well-defined membrane spanning alpha-helix.
    Title: Transmembrane organization of yeast syntaxin-analogue Sso1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore-type prospore assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore-type prospore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
syntaxin
NP_015092.1
  • Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    107275..108147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184046.1 → NP_015092.1  TPA: syntaxin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3D8, P32867
    UniProtKB/TrEMBL
    A6ZW23, B3LKJ9, B5VSV0, C7GU71, C8ZIE7, G2WNV3, N1P2I2
    Conserved Domains (1) summary
    COG5074
    Location:1 → 268
    COG5074; t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32867.2

Gene LinkOut

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