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CIN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855835, updated on 11-Sep-2024

Summary

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Official Symbol
CIN2
Primary source
SGD:S000006162
Locus tag
YPL241C
See related
AllianceGenome:SGD:S000006162; FungiDB:YPL241C; VEuPathDB:YPL241C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in protein folding and tubulin complex assembly. Predicted to be located in microtubule. Predicted to be active in cytoplasm. Used to study retinitis pigmentosa. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (95372..96258, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene signal recognition particle subunit SRP68 Neighboring gene Iqg1p Neighboring gene Hsp90 family chaperone HSP82 Neighboring gene Yar1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt MA, et al. Mol Cell Biol, 1990 Jan. PMID 2403635, Free PMC Article
  2. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Nithianantham S, et al. Elife, 2015 Jul 24. PMID 26208336, Free PMC Article
  3. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Stearns T, et al. Genetics, 1990 Feb. PMID 2407611, Free PMC Article
  4. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. Berlin V, et al. J Cell Biol, 1990 Dec. PMID 2277073, Free PMC Article
  5. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Veltel S, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18376416

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein CIN2
NP_015083.1
  • GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    95372..96258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184055.1 → NP_015083.1  TPA: GTPase-activating protein CIN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3D0, P46670, Q08973
    UniProtKB/TrEMBL
    A6ZW15, B3LKJ1, C8ZID8, G2WNU5, N1NXN5
    Conserved Domains (1) summary
    cl29757
    Location:118 → 220
    TBCC; Tubulin binding cofactor C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46670.2

Gene LinkOut

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