YAH1 adrenodoxin [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YAH1
Official Full Name: adrenodoxin
Primary source: SGD:S000006173
Locus tag: YPL252C
See related: AllianceGenome:SGD:S000006173; FungiDB:YPL252C; VEuPathDB:YPL252C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in heme A biosynthetic process; iron-sulfur cluster assembly; and ubiquinone biosynthetic process. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial myopathy. Orthologous to human FDX2 (ferredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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required for Fe/S cluster synthesis on Isu1
Title: Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin.
investigation of role of YAH1 (and Aft-1) in regulation of iron metabolism under various growth conditions (e.g., low iron in media)
Title: Biophysical investigation of the iron in Aft1-1(up) and Gal-YAH1 Saccharomyces cerevisiae.
EPR, Mossbauer spectroscopy, and electron microscopy were used to characterize the Fe that accumulates in Yah1p-depleted isolated intact mitochondria
Title: EPR and Mössbauer spectroscopy of intact mitochondria isolated from Yah1p-depleted Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IGI Inferred from Genetic Interaction more info	PubMed
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in P450-containing electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme A biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heme A biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_015071.1

Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1