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NOG2 putative GTPase NOG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855789, updated on 18-Sep-2024

Summary

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Official Symbol
NOG2
Official Full Name
putative GTPase NOG2
Primary source
SGD:S000005336
Locus tag
YNR053C
See related
AllianceGenome:SGD:S000005336; FungiDB:YNR053C; VEuPathDB:YNR053C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NUG2
Summary
Enables large ribosomal subunit rRNA binding activity. Involved in regulation of ribosomal subunit export from nucleus and ribosomal large subunit export from nucleus. Located in nucleolus and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NOG2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (721120..723112, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Bre5p Neighboring gene CCR4-NOT core DEDD family RNase subunit POP2 Neighboring gene ncRNA Neighboring gene RNA-binding ATPase activator ESF2 Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae. Białkowska A, et al. Acta Biochim Pol, 2002. PMID 12362983
  2. Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis. Talkish J, et al. RNA, 2016 Jun. PMID 27036125, Free PMC Article
  3. OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. Liu S, et al. EMBO Rep, 2021 Apr 7. PMID 33655635, Free PMC Article
  4. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Lebreton A, et al. J Biol Chem, 2006 Sep 15. PMID 16861225
  5. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits from the nucleolus.
    Title: Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits from the nucleolus.
  2. Nug2 is a regulatory GTPase that monitors pre-60S maturation, with release from its placeholder site linked to recruitment of the nuclear export machinery
    Title: Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables large ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative GTPase NOG2
NP_014451.1
  • Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    721120..723112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183230.1 → NP_014451.1  TPA: putative GTPase NOG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1M8, P53742
    UniProtKB/TrEMBL
    A6ZSC7, B3LPJ0, C8ZFT2, G2WLB0
    Conserved Domains (2) summary
    cd01858
    Location:214 → 370
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    pfam08153
    Location:41 → 171
    NGP1NT; NGP1NT (NUC091) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53742.1

Gene LinkOut

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