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YNR048W putative aminophospholipid translocase regulatory protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 855784, updated on 17-May-2024

Summary

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Gene symbol
YNR048W
Gene description
putative aminophospholipid translocase regulatory protein
Primary source
FungiDB:YNR048W
Locus tag
YNR048W
See related
SGD:S000005331; AllianceGenome:SGD:S000005331; VEuPathDB:YNR048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRF1
Summary
Involved in phospholipid translocation. Located in trans-Golgi network. Orthologous to human TMEM30A (transmembrane protein 30A) and TMEM30B (transmembrane protein 30B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YNR048W in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (711630..712811)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene RNA methylation protein TRM112 Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene Mso1p Neighboring gene saccharopine dehydrogenase (NADP+, L-glutamate-forming)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. Hanson PK, et al. J Biol Chem, 2003 Sep 19. PMID 12842877
  2. Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p. Lenoir G, et al. J Biol Chem, 2009 Jul 3. PMID 19411703, Free PMC Article
  3. Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Katoh Y, et al. Oncol Rep, 2004 Oct. PMID 15375526
  4. The cloning and characterization of the CDC50 gene family in Saccharomyces cerevisiae. Radji M, et al. Yeast, 2001 Feb. PMID 11180453
  5. Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Saito K, et al. Mol Biol Cell, 2004 Jul. PMID 15090616, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
putative aminophospholipid translocase regulatory protein
NP_014446.3
  • Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    711630..712811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183225.3 → NP_014446.3  TPA: putative aminophospholipid translocase regulatory protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014446.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1M3, P53740
    UniProtKB/TrEMBL
    A0A8H4F812, A6ZSC2, B3LPJ5, B5VR73, C7GLK9, C8ZFS7, G2WLA5, N1P4U7
    Conserved Domains (1) summary
    COG5035
    Location:3 → 375
    CDC50; Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53740.1

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