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SPO1 putative carboxylic ester hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855720, updated on 2-Nov-2024

Summary

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Official Symbol
SPO1
Official Full Name
putative carboxylic ester hydrolase
Primary source
SGD:S000004957
Locus tag
YNL012W
See related
AllianceGenome:SGD:S000004957; FungiDB:YNL012W; VEuPathDB:YNL012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable phospholipase A2 activity. Involved in meiosis I; spindle pole body duplication; and spore membrane bending pathway. Located in endoplasmic reticulum; nucleus; and prospore membrane. Orthologous to several human genes including PLA2G4C (phospholipase A2 group IVC) and PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPO1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (609686..611665)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pbi2p Neighboring gene translation elongation factor EF-3 Neighboring gene uncharacterized protein Neighboring gene putative phosphoric monoester hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SPO1 gene product required for meiosis in yeast has a high similarity to phospholipase B enzymes. Tevzadze GG, et al. Gene, 1996 Oct 24. PMID 8921875
  2. Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence. Verhasselt P, et al. Yeast, 1994 Jul. PMID 7985421
  3. Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae. Tevzadze GG, et al. Chromosoma, 2000. PMID 10855497
  4. SPO71 mediates prospore membrane size and maturation in Saccharomyces cerevisiae. Parodi EM, et al. Eukaryot Cell, 2012 Oct. PMID 22611022, Free PMC Article
  5. The Dysferlin Domain-Only Protein, Spo73, Is Required for Prospore Membrane Extension in Saccharomyces cerevisiae. Okumura Y, et al. mSphere, 2016 Jan-Feb. PMID 27303688, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the SpoMBe pathway of Sma2p and Spo1p involves asymmetric distribution of Sma2p and does not involve a GPI-protein-containing matrix
    Title: The SpoMBe pathway drives membrane bending necessary for cytokinesis and spore formation in yeast meiosis.
  2. A Spo1-dependent, meiosis-specific signaling pathway is required for progression of MI, MII, and spore formation via regulation of the spindle pole body .
    Title: Genetic evidence for a SPO1-dependent signaling pathway controlling meiotic progression in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore-type prospore membrane formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore-type prospore membrane formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle pole body duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spore membrane bending pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spore membrane bending pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative carboxylic ester hydrolase
NP_014386.2
  • Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    609686..611665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182851.1 → NP_014386.2  TPA: putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014386.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1G5, P53541
    UniProtKB/TrEMBL
    C8ZFL4, N1NY35
    Conserved Domains (1) summary
    smart00022
    Location:19 → 629
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53541.2

Gene LinkOut

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