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GPI15 phosphatidylinositol N-acetylglucosaminyltransferase GPI15 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855690, updated on 2-Nov-2024

Summary

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Official Symbol
GPI15
Official Full Name
phosphatidylinositol N-acetylglucosaminyltransferase GPI15
Primary source
SGD:S000004983
Locus tag
YNL038W
See related
AllianceGenome:SGD:S000004983; FungiDB:YNL038W; VEuPathDB:YNL038W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GPI15 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (557020..557783)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative alanine--tRNA ligase Neighboring gene transcription factor TFIIIB subunit BDP1 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH1 Neighboring gene carbonate dehydratase NCE103

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly. Yan BC, et al. Yeast, 2001 Nov. PMID 11746600
  2. Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. Fu Y, et al. Nat Commun, 2020 Jul 7. PMID 32636417, Free PMC Article
  3. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Kajiwara K, et al. Mol Biol Cell, 2008 May. PMID 18287539, Free PMC Article
  4. Synthetic lethality of cohesins with PARPs and replication fork mediators. McLellan JL, et al. PLoS Genet, 2012. PMID 22412391, Free PMC Article
  5. Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. Dubarry M, et al. G3 (Bethesda), 2015 Aug 21. PMID 26297725, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
Inferred from Electronic Annotation
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase GPI15
NP_014360.2
  • Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    557020..557783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182877.1 → NP_014360.2  TPA: phosphatidylinositol N-acetylglucosaminyltransferase GPI15 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014360.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1E1, P53961, Q6B1G8
    UniProtKB/TrEMBL
    A6ZS40, B3LNQ0, C7GLW2, C8ZFV4, G2WM65, N1NWP5
    Conserved Domains (1) summary
    pfam10181
    Location:123 → 197
    PIG-H; GPI-GlcNAc transferase complex, PIG-H component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53961.2

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