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COG5 Golgi transport complex subunit COG5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855676, updated on 2-Nov-2024

Summary

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Official Symbol
COG5
Official Full Name
Golgi transport complex subunit COG5
Primary source
SGD:S000004996
Locus tag
YNL051W
See related
AllianceGenome:SGD:S000004996; FungiDB:YNL051W; VEuPathDB:YNL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
API4; COD4
Summary
Involved in cytoplasm to vacuole targeting by the Cvt pathway and intra-Golgi vesicle-mediated transport. Located in cytosol. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COG5 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (532659..533870)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene cytochrome c oxidase subunit Va Neighboring gene uncharacterized protein Neighboring gene COPII subunit SFB2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Ha JY, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331899, Free PMC Article
  2. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. Fotso P, et al. J Biol Chem, 2005 Jul 29. PMID 15932880
  3. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article
  4. Detailed Analysis of the Interaction of Yeast COG Complex. Ishii M, et al. Cell Struct Funct, 2018 Jul 19. PMID 29899178, Free PMC Article
  5. Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production. Huang M, et al. Proc Natl Acad Sci U S A, 2018 Nov 20. PMID 30397111, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi transport complex subunit COG5
NP_014347.1
  • Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    532659..533870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182890.1 → NP_014347.1  TPA: Golgi transport complex subunit COG5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1C8, P53951
    UniProtKB/TrEMBL
    B3LNR2, B5VQZ0, C8ZGH7, N1NY12
    Conserved Domains (1) summary
    pfam10392
    Location:14 → 146
    COG5; Golgi transport complex subunit 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53951.1

Gene LinkOut

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