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VAC7 Vac7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855673, updated on 2-Nov-2024

Summary

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Official Symbol
VAC7
Official Full Name
Vac7p
Primary source
SGD:S000004999
Locus tag
YNL054W
See related
AllianceGenome:SGD:S000004999; FungiDB:YNL054W; VEuPathDB:YNL054W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in positive regulation of phosphatidylinositol biosynthetic process and protein localization to vacuolar membrane. Located in fungal-type vacuole membrane. Part of PAS complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VAC7 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (526086..529583)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene cytochrome c oxidase subunit Va

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation. Gomes de Mesquita DS, et al. Eur J Cell Biol, 1996 Nov. PMID 8929562
  2. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary JD, et al. J Cell Biol, 1998 Oct 5. PMID 9763421, Free PMC Article
  3. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Rudge SA, et al. Mol Biol Cell, 2004 Jan. PMID 14528018, Free PMC Article
  4. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins. Levine TP. Proteins, 2022 Jan. PMID 34347309
  5. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary JD, et al. Mol Biol Cell, 2002 Apr. PMID 11950935, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
    Title: TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to vacuolar membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole inheritance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PAS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PAS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vac7p
NP_014344.3
  • Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    526086..529583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182893.3 → NP_014344.3  TPA: Vac7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014344.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1C5, P53950
    UniProtKB/TrEMBL
    G2WM49, N1NZI9
    Conserved Domains (1) summary
    pfam12751
    Location:923 → 1001
    Vac7; Vacuolar segregation subunit 7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53950.1

Gene LinkOut

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