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TPM1 tropomyosin TPM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855645, updated on 2-Nov-2024

Summary

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Official Symbol
TPM1
Official Full Name
tropomyosin TPM1
Primary source
SGD:S000005023
Locus tag
YNL079C
See related
AllianceGenome:SGD:S000005023; FungiDB:YNL079C; VEuPathDB:YNL079C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables actin lateral binding activity. Involved in actin cytoskeleton organization; cellular hyperosmotic response; and pseudohyphal growth. Located in actin filament bundle and cellular bud neck contractile ring. Is active in actin filament. Human ortholog(s) of this gene implicated in congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to human TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TPM1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (478566..479165, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative mitochondrial 37S ribosomal protein SWS2 Neighboring gene Eos1p Neighboring gene Nis1p Neighboring gene Apj1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myo2p is not processive on bare actin but highly processive on actin-tropomyosin. Tpm1p supports the most robust processivity.
    Title: Tropomyosin is essential for processive movement of a class V myosin from budding yeast.
  2. Results show that yeast cofilin 1 can efficiently depolymerize and sever yeast actin filaments decorated with either tropomyosin (Tpm)1 or mouse tropomyosins TM1 and TM4.
    Title: Intrinsic capability of budding yeast cofilin to promote turnover of tropomyosin-bound actin filaments.
  3. Ultra short yeast tropomyosins show novel myosin regulation
    Title: Ultra short yeast tropomyosins show novel myosin regulation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin lateral binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tropomyosin TPM1
NP_014320.1
  • Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    478566..479165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182917.1 → NP_014320.1  TPA: tropomyosin TPM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014320.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1A0, P17536, Q45TY1
    UniProtKB/TrEMBL
    A6ZS01, B3LNT8, C7GUM9, C8ZGF1, G2WM25, N1NXI5
    Conserved Domains (1) summary
    pfam12718
    Location:7 → 186
    Tropomyosin_1; Tropomyosin like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17536.1

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