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MIC27 Mic27p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855623, updated on 18-Sep-2024

Summary

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Official Symbol
MIC27
Official Full Name
Mic27p
Primary source
SGD:S000005044
Locus tag
YNL100W
See related
AllianceGenome:SGD:S000005044; FungiDB:YNL100W; VEuPathDB:YNL100W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM37; MCS27
Summary
Involved in cristae formation and protein-containing complex subunit organization. Located in mitochondrial crista junction. Part of MICOS complex. Colocalizes with fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MIC27 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (437613..438317)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase alpha catalytic subunit POL1 Neighboring gene Avt4p Neighboring gene putative tyrosine protein phosphatase OCA1 Neighboring gene Ras family GTPase RAS2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. Rampelt H, et al. J Mol Biol, 2018 Jun 22. PMID 29733859
  2. Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Stoldt S, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028145, Free PMC Article
  3. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
  4. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
  5. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results find that Mic26 and Mic27 regulate Mic10 oligomerization in an antagonistic manner.
    Title: Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.
  2. in addition to the MICOS core components Mic10 and Mic60, Mic12 and Mic27 play specific roles in the organization of the MICOS complex
    Title: Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial crista junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mic27p
NP_014299.1
  • Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; orthologous to human APOO and APOOL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    437613..438317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182938.1 → NP_014299.1  TPA: Mic27p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014299.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZRY0, B3LNV9, B5VQU2, C7GR78, D6W179, P50945, Q45U03
    UniProtKB/TrEMBL
    G2WM04, N1NXX3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50945.1

Gene LinkOut

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