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NCS2 Ncs2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855603, updated on 2-Nov-2024

Summary

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Official Symbol
NCS2
Official Full Name
Ncs2p
Primary source
SGD:S000005063
Locus tag
YNL119W
See related
AllianceGenome:SGD:S000005063; FungiDB:YNL119W; VEuPathDB:YNL119W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TUC2
Summary
Predicted to enable sulfurtransferase activity. Involved in several processes, including invasive growth in response to glucose limitation; protein urmylation; and pseudohyphal growth. Located in cytoplasm. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NCS2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (401040..402521)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MRP35 Neighboring gene protein channel TOM70 Neighboring gene decapping enzyme complex catalytic subunit Neighboring gene malate synthase MLS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA. Alings F, et al. Nucleic Acids Res, 2023 Aug 25. PMID 37462076, Free PMC Article
  2. Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Sinha H, et al. Genetics, 2008 Nov. PMID 18780730, Free PMC Article
  3. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. Yang Y, et al. PLoS Genet, 2013. PMID 23966873, Free PMC Article
  4. Global translational impacts of the loss of the tRNA modification t(6)A in yeast. Thiaville PC, et al. Microb Cell, 2016 Jan 1. PMID 26798630, Free PMC Article
  5. Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications. Bruch A, et al. Genes (Basel), 2018 Oct 23. PMID 30360492, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.
    Title: Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.
  2. Data shsow that loss of Ncs2, Nup60, or Pom152 led to an impaired ability to increase SPB size during metaphase arrest, implicating these proteins in SPB component assembly.
    Title: Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein urmylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein urmylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble position uridine thiolation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ncs2p
NP_014280.3
  • Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    401040..402521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182957.3 → NP_014280.3  TPA: Ncs2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014280.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B0KZR6, B0KZS5, B0KZU3, B0L006, B3LNX6, D6W163, P53923, Q66R25
    UniProtKB/TrEMBL
    C7GKC6, C8ZGB2, G2WLY7, N1NWJ2
    Conserved Domains (1) summary
    pfam10288
    Location:323 → 446
    CTU2; Cytoplasmic tRNA 2-thiolation protein 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53923.1

Gene LinkOut

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