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MFA2 mating pheromone a [ Saccharomyces cerevisiae S288C ]

Gene ID: 855577, updated on 3-Nov-2024

Summary

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Official Symbol
MFA2
Official Full Name
mating pheromone a
Primary source
SGD:S000005089
Locus tag
YNL145W
See related
AllianceGenome:SGD:S000005089; FungiDB:YNL145W; VEuPathDB:YNL145W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MFA2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (352414..352530)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene: mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences. Teng Y, et al. J Mol Biol, 1997 Mar 28. PMID 9096229
  2. Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Muhlrad D, et al. Genes Dev, 1992 Nov. PMID 1427074
  3. Histone acetylation, chromatin remodelling and nucleotide excision repair: hint from the study on MFA2 in Saccharomyces cerevisiae. Yu Y, et al. Cell Cycle, 2005 Aug. PMID 16082210
  4. Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Yuan YL, et al. Mol Cell Biol, 1991 Dec. PMID 1944269, Free PMC Article
  5. The mapping of nucleosomes and regulatory protein binding sites at the Saccharomyces cerevisiae MFA2 gene: a high resolution approach. Teng Y, et al. Nucleic Acids Res, 2001 Jul 1. PMID 11433040, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MFA2 mRNA was more rapidly deadenylated as well as significantly stabilized in the ccr4 deadenylation mutant in the edc3 lsm4C background. These results suggest a role for these decapping factors in stabilizing mRNA and may implicate P bodies as sites of reduced mRNA degradation.
    Title: An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress.
  2. MFA2 mRNAs are transported to the shmoo tip, in complex with processing body-like particles, where they are locally translated.
    Title: Pheromone-encoding mRNA is transported to the yeast mating projection by specific RNP granules.
  3. post-UV histone modifications and chromatin remodelling at the repressed MFA2 promoter do not activate MFA2 transcription, nor do they require damage recognition by Rad4p or Rad14p
    Title: Histone acetylation, chromatin remodelling and nucleotide excision repair: hint from the study on MFA2 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mating pheromone activity IEA
Inferred from Electronic Annotation
more info
  
enables mating pheromone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pheromone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mating pheromone a
NP_014254.1
  • Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    352414..352530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182983.1 → NP_014254.1  TPA: mating pheromone a [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014254.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W138, P34166
    UniProtKB/TrEMBL
    A6ZRT9, B3LP00, C7GXU5, C8ZG84, G2WLW2, N1NXD7
    Conserved Domains (1) summary
    pfam17317
    Location:1 → 38
    MFA1_2; Mating hormone A-factor 1_2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34166.1

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