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LSM7 Sm-like protein LSM7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855575, updated on 18-Sep-2024

Summary

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Official Symbol
LSM7
Official Full Name
Sm-like protein LSM7
Primary source
SGD:S000005091
Locus tag
YNL147W
See related
AllianceGenome:SGD:S000005091; FungiDB:YNL147W; VEuPathDB:YNL147W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome; maturation of SSU-rRNA; and nuclear-transcribed mRNA catabolic process. Located in cytoplasm and nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSM7 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (350940..351383)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pga2p Neighboring gene Alf1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exon sequences at the splice junctions affect splicing fidelity and alternative splicing. Crotti LB, et al. Proc Natl Acad Sci U S A, 2009 Nov 10. PMID 19855008, Free PMC Article
  2. The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA. Spiller MP, et al. Nucleic Acids Res, 2007. PMID 17251193, Free PMC Article
  3. The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. Yang S, et al. BMC Microbiol, 2010 May 7. PMID 20459639, Free PMC Article
  4. LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication. Galão RP, et al. RNA, 2010 Apr. PMID 20181739, Free PMC Article
  5. LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Luhtala N, et al. Nucleic Acids Res, 2009 Sep. PMID 19596813, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The middle domain of Pat1 is essential for the interaction of Pat1 with the Lsm1-7 complex in vivo.
    Title: Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.
  2. an Lsm2-Lsm7 protein complex resides in nucleoli, contributing to the biogenesis or function of specific snoRNAs
    Title: An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.
  3. The Lsm1p-7p-Pat1p complex protects mRNAs by binding at/near the 3'end and distinguishes between oligoadenyLated and polyadenylated RNA.
    Title: The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Lsm1-7-Pat1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sm-like protein LSM7
NP_014252.2
  • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    350940..351383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182985.1 → NP_014252.2  TPA: Sm-like protein LSM7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014252.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W135, P53905
    UniProtKB/TrEMBL
    B3LP03, C7GXU8, C8ZG81, G2WLV9, N1NXT8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53905.2

Gene LinkOut

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