U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

INN1 Inn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855570, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
INN1
Official Full Name
Inn1p
Primary source
SGD:S000005096
Locus tag
YNL152W
See related
AllianceGenome:SGD:S000005096; FungiDB:YNL152W; VEuPathDB:YNL152W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Involved in chromosome organization and secondary cell septum biogenesis. Located in cellular bud neck contractile ring. Part of HICS complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See INN1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (346313..347542)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase YCK2 Neighboring gene tubulin-binding prefolding complex subunit GIM3 Neighboring gene DNA-directed RNA polymerase III subunit C31 Neighboring gene Pga2p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Sanchez-Diaz A, et al. Nat Cell Biol, 2008 Apr. PMID 18344988
  2. Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. Wang M, et al. Mol Biol Cell, 2018 Mar 1. PMID 29321253, Free PMC Article
  3. Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. Devrekanli A, et al. J Cell Sci, 2012 Nov 15. PMID 22956544
  4. Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck. Jendretzki A, et al. Mol Genet Genomics, 2009 Oct. PMID 19707790
  5. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. Naylor SG, et al. J Cell Sci, 2014 Mar 1. PMID 24413167, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a new and widely applicable tool to generate conditionally phosphorylated proteins to identify those whose dephosphorylation is required for cytokinesis. This approach identifies Aip1, Ede1 and Inn1 as cytokinetic regulators.
    Title: Identification of Cdk targets that control cytokinesis.
  2. Dephosphorylation of Inn1 is important for its function in promoting cytokinesis.
    Title: Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.
  3. Cyk3 is part of an actomyosin ring independent cytokinesis pathway, which acts as a rescue mechanism to recruit Inn1 to the bud neck.
    Title: Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.
  4. Data show that the Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis proteins Hof1 and Cyk3.
    Title: Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
  5. Data indicate that recruitment of the C2 domain of Inn1 to the contractile actomyosin ring is crucial for ingression of the plasma membrane during cytokinesis in budding yeast.
    Title: Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secondary cell septum biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in secondary cell septum biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HICS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Inn1p
NP_014247.1
  • Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    346313..347542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182990.1 → NP_014247.1  TPA: Inn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014247.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W131, P53901, Q6Q5J6
    UniProtKB/TrEMBL
    B3LP07, C7GXV2, C8ZG76, N1NZA7
    Conserved Domains (1) summary
    cd08681
    Location:11 → 133
    C2_fungal_Inn1p-like; C2 domain found in fungal Ingression 1 (Inn1) proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53901.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools