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GIM3 tubulin-binding prefolding complex subunit GIM3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855569, updated on 3-Nov-2024

Summary

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Official Symbol
GIM3
Official Full Name
tubulin-binding prefolding complex subunit GIM3
Primary source
SGD:S000005097
Locus tag
YNL153C
See related
AllianceGenome:SGD:S000005097; FungiDB:YNL153C; VEuPathDB:YNL153C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PFD4
Summary
Enables tubulin binding activity. Involved in cytoplasm protein quality control by the ubiquitin-proteasome system; positive regulation of transcription elongation by RNA polymerase II; and tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIM3 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (345669..346058, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cuz1p Neighboring gene serine/threonine protein kinase YCK2 Neighboring gene Inn1p Neighboring gene DNA-directed RNA polymerase III subunit C31

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Absence of Gim proteins, but not GimC complex, alters stress-induced transcription. Amorim AF, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jul. PMID 28457997
  2. Environmental robustness of the global yeast genetic interaction network. Costanzo M, et al. Science, 2021 May 7. PMID 33958448, Free PMC Article
  3. Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. Siegers K, et al. EMBO J, 1999 Jan 4. PMID 9878052, Free PMC Article
  4. Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility. Comyn SA, et al. PLoS Genet, 2016 Jul. PMID 27448207, Free PMC Article
  5. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew CT, et al. Genetics, 2002 Nov. PMID 12454057, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tubulin-binding prefolding complex subunit GIM3
NP_014246.1
  • Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    345669..346058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182991.1 → NP_014246.1  TPA: tubulin-binding prefolding complex subunit GIM3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014246.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W130, P53900
    UniProtKB/TrEMBL
    A6ZRT1, B3LP08, C7GXV3, C8ZG75, G2WLV4, N1NXT5
    Conserved Domains (1) summary
    COG1382
    Location:4 → 129
    GimC; Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53900.1

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