YCK2 serine/threonine protein kinase YCK2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YCK2
Official Full Name: serine/threonine protein kinase YCK2
Primary source: SGD:S000005098
Locus tag: YNL154C
See related: AllianceGenome:SGD:S000005098; FungiDB:YNL154C; VEuPathDB:YNL154C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase activity. Involved in cell morphogenesis; endocytosis; and glucose mediated signaling pathway. Located in cellular bud neck; mating projection; and plasma membrane. Orthologous to several human genes including CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YCK2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (343636..345276, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Compared with wild-type mitochondria, yck2 mitochondria revealed slower persulfide formation on Nfs1 consistent with a role of Yck2 in regulating mitochondrial cysteine desulfurase activity.
Title: Cysteine desulfurase is regulated by phosphorylation of Nfs1 in yeast mitochondria.
Data show that the pheromone-responsive G protein subunits beta/gamma (Gbetagamma; STE4/STE18) dimer promotes the polarization of the pheromone receptor by interacting with casein kinases 1 or 2 (Yck1/2) and locally inhibiting receptor phosphorylation.
Title: Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.
Yck1p and Yck2p phosphorylate sites within the Sec2p Ypt32p/Sec15p binding region and in doing so promote binding of Sec2p to Sec15p and inhibit binding to Ypt32p.
Title: The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p.
The yeast kinase Yck2 has a tripartite palmitoylation signal.
Title: The yeast kinase Yck2 has a tripartite palmitoylation signal.
there are overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation in yeast.
Title: Overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine protein kinase YCK2

NP_014245.1

EC 2.7.11.1

Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

343636..345276 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182992.1 → NP_014245.1 TPA: serine/threonine protein kinase YCK2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014245.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W129, P23292

UniProtKB/TrEMBL

B3LP09, C7GXV4

Conserved Domains (1) summary

cd14127
Location:75 → 351

STKc_CK1_fungal; Catalytic domain of the Serine/Threonine protein kinase, Fungal Casein Kinase 1 homolog 1