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RAP1 DNA-binding transcription factor RAP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855505, updated on 2-Nov-2024

Summary

Official Symbol
RAP1
Official Full Name
DNA-binding transcription factor RAP1
Primary source
SGD:S000005160
Locus tag
YNL216W
See related
AllianceGenome:SGD:S000005160; FungiDB:YNL216W; VEuPathDB:YNL216W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GRC4; GRF1; TBA1; TUF1
Summary
Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and general transcription initiation factor binding activity. Involved in several processes, including establishment of protein localization to chromosome; regulation of gene expression; and telomere organization. Located in chromosome, telomeric region; cytosol; and nuclear chromosome. Part of shelterin complex. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See RAP1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (241689..244172)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ssDNA-dependent ATPase MGS1 Neighboring gene putative serine/threonine-protein phosphatase Neighboring gene Ies2p Neighboring gene Pex17p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in G-quadruplex DNA formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of protein localization to chromatin IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in establishment of protein localization to telomere IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protection from non-homologous end joining at telomere IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in silent mating-type cassette heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in subtelomeric heterochromatin formation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance via telomere lengthening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of shelterin complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-binding transcription factor RAP1
NP_014183.1
  • Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    241689..244172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183054.1NP_014183.1  TPA: DNA-binding transcription factor RAP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014183.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0X4, P11938
    UniProtKB/TrEMBL
    A6ZRM4, B3LP60, C8ZG17, G2WLP7
    Conserved Domains (4) summary
    cd11653
    Location:727824
    rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
    cd11655
    Location:360413
    rap1_myb-like; DNA-binding modules of yeast Rap1 and related proteins
    pfam09197
    Location:448579
    Rap1-DNA-bind; Rap1, DNA-binding
    pfam16589
    Location:127207
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain