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SQS1 Sqs1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855497, updated on 18-Sep-2024

Summary

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Official Symbol
SQS1
Official Full Name
Sqs1p
Primary source
SGD:S000005168
Locus tag
YNL224C
See related
AllianceGenome:SGD:S000005168; FungiDB:YNL224C; VEuPathDB:YNL224C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PFA1
Summary
Predicted to enable nucleic acid binding activity. Involved in RNA processing; positive regulation of ATPase activity; and positive regulation of helicase activity. Located in cytoplasm and nucleolus. Part of 90S preribosome; preribosome, large subunit precursor; and preribosome, small subunit precursor. Orthologous to human GPATCH2 (G-patch domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SQS1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (224796..227099, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Jjj1p Neighboring gene Cnm67p Neighboring gene cysteine protease ATG4 Neighboring gene RNA polymerase II subunit A C-terminal domain phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prp43p contains a processive helicase structural architecture with a specific regulatory domain. Walbott H, et al. EMBO J, 2010 Jul 7. PMID 20512115, Free PMC Article
  2. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase. Mouffok S, et al. RNA Biol, 2021 Apr. PMID 32882145, Free PMC Article
  3. Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae. Banerjee D, et al. Genetics, 2015 May. PMID 25808954, Free PMC Article
  4. RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1. Pertschy B, et al. J Biol Chem, 2009 Dec 11. PMID 19801658, Free PMC Article
  5. The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. Lebaron S, et al. EMBO J, 2009 Dec 16. PMID 19927118, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
    Title: The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
  2. Data report that cleavage of pre-rRNA at the 3'-end of 18 S rRNA, requires functional interactions between Nob1 and Prp43, and the cofactor Pfa1.
    Title: RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.
  3. stimulation of ATPase/helicase activities of Prp43p by Pfa1p is required for efficient 20S pre-rRNA-to-18S rRNA conversion
    Title: The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maturation of SSU-rRNA IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in rRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, small subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sqs1p
NP_014175.1
  • Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    224796..227099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183062.1 → NP_014175.1  TPA: Sqs1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZRL6, D6W0W6, P53866
    UniProtKB/TrEMBL
    B3LP68, N1NY27
    Conserved Domains (2) summary
    cd02646
    Location:597 → 654
    R3H_G-patch; R3H domain of a group of fungal and plant proteins with unknown function, who also contain a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the R3H ...
    pfam01585
    Location:721 → 764
    G-patch; G-patch domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53866.1

Gene LinkOut

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