U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GOR1 glyoxylate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855447, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
GOR1
Official Full Name
glyoxylate reductase
Primary source
SGD:S000005218
Locus tag
YNL274C
See related
AllianceGenome:SGD:S000005218; FungiDB:YNL274C; VEuPathDB:YNL274C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glyoxylate reductase (NADH) activity. Involved in glyoxylate catabolic process. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GOR1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (121118..122170, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene homoserine O-acetyltransferase Neighboring gene Bor1p Neighboring gene Tof1p Neighboring gene guanine nucleotide exchange factor SEC2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae. Rintala E, et al. Yeast, 2007 Feb. PMID 17173333
  2. A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae. Dickinson JR, et al. J Biol Chem, 1997 Oct 24. PMID 9341119
  3. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers E, et al. J Biol Chem, 2003 Mar 21. PMID 12525494
  4. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945
  5. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GOR1 codes for glyoxalate reductase in Saccharomyces cerevisiae.
    Title: The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxylate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase [NAD(P)H] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glyoxylate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glyoxylate reductase
NP_014125.1
  • Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    121118..122170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183112.1 → NP_014125.1  TPA: glyoxylate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014125.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0S0, P53839
    UniProtKB/TrEMBL
    A6ZRH0, B3LPB3, B5VQE0, C7GP89, C8ZGP8, G2WLJ2, N1NWX8
    Conserved Domains (1) summary
    cd12168
    Location:4 → 329
    Mand_dh_like; D-Mandelate Dehydrogenase-like dehydrogenases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53839.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools