ERG24 delta(14)-sterol reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERG24
Official Full Name: delta(14)-sterol reductase
Primary source: SGD:S000005224
Locus tag: YNL280C
See related: AllianceGenome:SGD:S000005224; FungiDB:YNL280C; VEuPathDB:YNL280C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables delta14-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor) and TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG24 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (109095..110411, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables delta14-sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta14-sterol reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta14-sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables delta14-sterol reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delta(14)-sterol reductase

NP_014119.1

EC 1.3.1.70

C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

109095..110411 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183118.1 → NP_014119.1 TPA: delta(14)-sterol reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014119.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0R4, P32462

UniProtKB/TrEMBL

A6ZRG5, B3LPB9, B5VQD5, C7GP84, C8ZGP1, G2WLI6, N1NXX5

Conserved Domains (1) summary

pfam01222
Location:8 → 438

ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family