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MID1 Mid1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855425, updated on 18-Sep-2024

Summary

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Official Symbol
MID1
Official Full Name
Mid1p
Primary source
SGD:S000005235
Locus tag
YNL291C
See related
AllianceGenome:SGD:S000005235; FungiDB:YNL291C; VEuPathDB:YNL291C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables stretch-activated, cation-selective, calcium channel activity. Involved in calcium ion transport. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MID1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (84169..85815, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rab GTPase-activating protein MSB3 Neighboring gene pseudouridine synthase PUS4 Neighboring gene replication factor C subunit 3 Neighboring gene Pcl1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca2+ permeation. Ozeki-Miyawaki C, et al. Exp Cell Res, 2005 Nov 15. PMID 16202999
  2. Phe356 in the yeast Ca2+ channel component Mid1 is a key residue for viability after exposure to alpha-factor. Tada T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697255
  3. Molecular dissection of the hydrophobic segments H3 and H4 of the yeast Ca2+ channel component Mid1. Tada T, et al. J Biol Chem, 2003 Mar 14. PMID 12514173
  4. Amiodarone induces a caffeine-inhibited, MID1-depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae. Courchesne WE, et al. Mol Microbiol, 2003 Jan. PMID 12492866
  5. Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1. Maruoka T, et al. J Biol Chem, 2002 Apr 5. PMID 11796727

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
    Title: High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
  2. Therefore, H(+) extrusion by Pma1 may be important for Ca(2+) influx through Cch1/Mid1. These results suggest that Pma1 interacts physically with Cch1/Mid1 Ca(2+) channels to enhance their activity via its H(+) -pumping activity
    Title: Coupling of a voltage-gated Ca(2+) channel homologue with a plasma membrane H(+) -ATPase in yeast.
  3. Cch1 and Mid1 mediate the ethanol-induced Ca2+ flux.
    Title: Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae.
  4. Growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium.
    Title: The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables stretch-activated, monoatomic cation-selective, calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mid1p
NP_014108.1
  • Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    84169..85815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183129.1 → NP_014108.1  TPA: Mid1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014108.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Q2, P41821
    UniProtKB/TrEMBL
    A6ZSI7, B3LPC9, B5VQC6, C7GS54
    Conserved Domains (1) summary
    pfam12929
    Location:99 → 537
    Mid1; Stretch-activated Ca2+-permeable channel component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41821.1

Gene LinkOut

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