U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KRI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855408, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
KRI1
Primary source
SGD:S000005252
Locus tag
YNL308C
See related
AllianceGenome:SGD:S000005252; FungiDB:YNL308C; VEuPathDB:YNL308C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of 90S preribosome. Orthologous to human KRI1 (KRI1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (54122..55897, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Zim17p Neighboring gene Stb1p Neighboring gene serine/threonine/tyrosine protein kinase MCK1 Neighboring gene mitochondrial 37S ribosomal protein YmS18

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast. Zheng S, et al. J Biol Chem, 2014 Aug 15. PMID 24990943, Free PMC Article
  2. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. Sasaki T, et al. Mol Cell Biol, 2000 Nov. PMID 11027267, Free PMC Article
  3. Generation of Saccharomyces cerevisiae deletants and basic phenotypic analysis of eight novel genes from the left arm of chromosome XIV. Maftahi M, et al. Yeast, 1998 Feb. PMID 9544246
  4. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Hoareau-Aveilla C, et al. Nucleic Acids Res, 2012 Apr. PMID 22180534, Free PMC Article
  5. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Krr1p and the genes encoding ribosomal proteins it interacts with seem to be coordinately regulated at the level of transcription.
    Title: Functional and physical interactions of Krr1p, a Saccharomyces cerevisiae nucleolar protein.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Kri1p
NP_014091.1
  • Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    54122..55897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183146.1 → NP_014091.1  TPA: Kri1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0N7, P42846
    UniProtKB/TrEMBL
    A6ZSH2, C7GWQ5, C8ZGL6, N1NZG1
    Conserved Domains (2) summary
    pfam05178
    Location:326 → 397
    Kri1; KRI1-like family
    pfam12936
    Location:474 → 543
    Kri1_C; KRI1-like family C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42846.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools