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ELP6 Elongator subunit ELP6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855360, updated on 2-Nov-2024

Summary

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Official Symbol
ELP6
Official Full Name
Elongator subunit ELP6
Primary source
SGD:S000004929
Locus tag
YMR312W
See related
AllianceGenome:SGD:S000004929; FungiDB:YMR312W; VEuPathDB:YMR312W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAP3; KTI4; TOT6
Summary
Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in protein urmylation; regulation of transcription by RNA polymerase II; and tRNA wobble uridine modification. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ELP6 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (898405..899226)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative methyltransferase Neighboring gene Glc8p Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase Neighboring gene proteasome core particle subunit alpha 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
  2. Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Jablonowski D, et al. Mol Microbiol, 2001 Nov. PMID 11737649
  3. Crystal structure of elongator subcomplex Elp4-6. Lin Z, et al. J Biol Chem, 2012 Jun 15. PMID 22556426, Free PMC Article
  4. Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications. Bruch A, et al. Genes (Basel), 2018 Oct 23. PMID 30360492, Free PMC Article
  5. Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement. Setiaputra DT, et al. EMBO Rep, 2017 Feb. PMID 27872205, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein urmylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongator subunit ELP6
NP_014043.1
  • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    898405..899226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182823.1 → NP_014043.1  TPA: Elongator subunit ELP6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0D9, Q04868
    UniProtKB/TrEMBL
    A6ZN29, B3LMK0, B5VQ78, C8ZFI3, N1NYW7
    Conserved Domains (1) summary
    cd19479
    Location:32 → 221
    Elp456; Elongator subcomplex subunits Elp4, 5 and 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04868.1

Gene LinkOut

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