U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LIP1 sphingosine N-acyltransferase subunit LIP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855344, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
LIP1
Official Full Name
sphingosine N-acyltransferase subunit LIP1
Primary source
SGD:S000004913
Locus tag
YMR298W
See related
AllianceGenome:SGD:S000004913; FungiDB:YMR298W; VEuPathDB:YMR298W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in endoplasmic reticulum membrane. Part of acyl-CoA ceramide synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LIP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (863819..864271)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene serine C-palmitoyltransferase LCB1 Neighboring gene carboxypeptidase C PRC1 Neighboring gene dynein light intermediate chain Neighboring gene amidophosphoribosyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure and mechanism of a eukaryotic ceramide synthase complex. Xie T, et al. EMBO J, 2023 Dec 11. PMID 37953642,
  2. Lip1p: a novel subunit of acyl-CoA ceramide synthase. Vallée B, et al. EMBO J, 2005 Feb 23. PMID 15692566, Free PMC Article
  3. Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae. Tani M, et al. J Biochem, 2010 Nov. PMID 20709688
  4. Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae. Tani M, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22166213
  5. Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast. Ishino Y, et al. FEBS J, 2022 Jan. PMID 34492164

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
    Title: Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
  2. Lip1 is a single-span endoplasmic reticulum membrane protein that is required for ceramide synthesis in vivo and in vitro. [Lip1]
    Title: Lip1p: a novel subunit of acyl-CoA ceramide synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to sphingosine N-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ceramide biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acyl-CoA ceramide synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sphingosine N-acyltransferase subunit LIP1
NP_014027.1
  • Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    863819..864271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182807.1 → NP_014027.1  TPA: sphingosine N-acyltransferase subunit LIP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014027.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZN14, D6W0C5, Q03579
    UniProtKB/TrEMBL
    B3LMI6, C7GTK1, C8ZFG7, G2WL07, N1NYV7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03579.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools